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Mario and Luigi Vampire Saga is a rated M Mario Game where Mario and Luigi have vampire power to fly and suck enemies blood which fuels their health and makes them strong and able to defeat enemies and break things well.
In the final episode of the Super Mario World Cartoon, Mario uses a pump full of lava and send's it through a warp pipe to Bowser's bedroom. It quickly fills up the bedroom trapping Bowser on his bed. The Koopalings are unable to help him so the lava level eventually fills up over his bed causing him to die in the lava
The Koopalings are sad about it, and when they tell Kamek about it, Kamek comes up with an idea to travel back in time to tell his past self to scientifically and magically mutate Baby Bowser's DNA with Dragon DNA so that Bowser would be able to breathe fire and also be immune to the lava so he wouldn't die when his room was filled with lava.
So in order to travel back in time Kamek stole Professor E Gad's time machine. E Gad was so angry about it that he overheated causing him to blow up and die. Kamek says "Wow E Gad. That was a pathetic FAIL!" and then he travels back in time.
Back in time he tells his past self to mutate Baby Bowser's DNA(which is why Bowser in the cartoon reality looks different in the video game reality) and also about the future Mario Bros in case Kamek will be able to stop them in the past before they become adults. That is how that Kamek in the past knew about the Mario Bros and tried kidnapping them in Yoshi's Island.
This causes reality to change where Bowser is immune to the lava. He is therefore able to reverse the pump so that it will go through the warp pipe to dome city on Yoshi's Island. This causes Dome City to be destroyed. Mario, Luigi, and Princess Toadstool are the only survivors
Luigi says, "Yay that annoying retard called Oogtar is dead! Praise The Lord Almighty". Mario says "Yeah but I accidentally left my condom in the city when I had sex with cavewomen there. Now it is destroyed by the lava" Princess Toadstool gets angry that Mario cheated on her so she blows up and dies. Luigi then remembers that he left his condom in Dome City as well. So they decide to travel back in time to get their condoms out of the city before it is destroyed.
So they go to the Mushroom Kingdom to borrow E Gad's time machine. However a Koopa Spy heard about the plan, and reported it to Bowser. Bowser didn't want the Mario bros from Saving their condoms because it would also save Princess Toadstool's life and since this was before he had a crush on Peach, he wanted her dead so that he could take over the Mushroom Kingdom. So he stole E Gad's time machine to prevent them from going back in time causing E Gad to get angry, blow up and die. Mario and Luigi are thirsty so they drink E Gad's blood which makes them extra strong.
So they decided to stay outside that night in the full moon and have the light shine on them making them turn into vampires. Then they start their adventure to rescue E Gad's time machine before the night is over and their Vampire powers wear out. However Bowser sends his minions to try to stop them on their adventure
The gameplay has 8 worlds and 8 levels per world. The 4th level of the world is a fortress where a Koopaling is battled and the 8th level is a castle where a monster is battled
|World||Info||Fortress Boss||Castle Boss|
|World 1 Mushroom Plains at Night||A grassy world with Mushroom Plains||Larry Koopa||Spore the Mutant Mushroom Vampire|
|World 2 The Forrest at Night||The forest at night||Ludwig Von Koopa||King Boo|
|World 3 Mountains at Night||The Mountains at Night||Iggy Koopa||Haunted Rock Monster|
|World 3 The Beach at Night||The beach at night||Wendy O Koopa||The Ghost of Redbeard the Koopa Pirate|
|World 5 The Icelands at Night||The cold world of Ice at Night||Lemmy Koopa||Jack Frost|
|World 6 the Desert at Night||The Desert at Night||Morton Koopa Jr||The Ghost of Ancient Pharaoh Koopa|
|World 7 The Sky at Night||The Sky at Night||Roy Koopa||The Spirit of Wind|
|World 8 Bowser's Volcano Kingdom||Bowser's volcano Kingdom||Bowser Koopa||Bowser Koopa in Vampire Form|
In the final level in World 8 which is Bowser's castle, The light of the full moon hits Bowser turning him into a vampire. Mario battles Bowser in his Vampire form and defeats him, but Vampire Bowser eats a mega Mushroom and grows big. Mario defeats him a second time. Therefore Mario and Luigi save the time machine and travel back In time to save their condoms before Dome City was flooded with lava, and Princess Toadstool/Peach lived after that.